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Evaluation of mitochondrial damage and ROS production. (A) CLSM images of JC-1 stained A2780/DDP cells after treatment with PBS, DDP, DMON@DDP, and TPP-DMON@DDP. Scale bar = 20 μm. (B) Relative intracellular ATP content of A2780/DDP cells after incubation with PBS, DDP, DMON@DDP, and TPP-DMON@DDP (*p < 0.05, **p < 0.01, ***p < 0.001, n = 6). (C) CLSM images of DCFH-DA stained A2780/DDP cells after exposure to PBS, DDP, DMON@DDP, and TPP-DMON@DDP. Scale bar = 50 μm.
