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. 2022 May 9;13:897046. doi: 10.3389/fphar.2022.897046

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Copyright © 2022 Zheng, Wang, Chen, Chen, Wu, Hu and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of the Src inhibitor PP2 on the biochemical and histopathological characteristics of db/db mice. (A) Body weight changes in the control (db/m) mice, diabetic (db/db) mice and PP2-treated db/db mice from 8 to 16 weeks of age. (B) Blood glucose levels in each group. (C) Food intake. (D) Urine volumes in 24 h. (E) Left kidney weights. (F) Serum creatinine levels. (G) HE, PAS and Masson’s staining were used to evaluate the histological changes and glomerulus damage in each treatment group (Magnification, 400 ×). Values are expressed as the mean ± SD, ^* p < 0.05 vs. db/m group; ^# p < 0.05 vs. db/db group. n = 5.