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. 2022 May 9;13:897046. doi: 10.3389/fphar.2022.897046

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Copyright © 2022 Zheng, Wang, Chen, Chen, Wu, Hu and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of Src activity increases mitophagy during DN. (A) The expression levels of FUNDC1, p-FUNDC1, LC3, P62 in kidney tissues from the different groups were analyzed by Western blot. (B–D) Quantitative analysis of gray values of bands from Western blots, GAPDH was used as loading control. (E) Representative images of LC3 (red) staining in glomeruli in kidney tissues from the different groups. Podocytes were marked by Nephrin staining (green). (Magnification, 600 ×). (F) Representative TEM images demonstrating mitophagosomes (mitophagosomes engulfing mitochondria) in podocytes from the different groups. Red arrows denote typical mitophagosomes. (Magnification, 5000 ×). (G) Quantification of mitophagosomes numbers from the experiment in (F). Values are expressed as the mean ± SD, ^* p < 0.05 vs. db/m group; ^# p < 0.05 vs. db/db group. n = 5.