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. 2022 May 9;13:897046. doi: 10.3389/fphar.2022.897046

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Copyright © 2022 Zheng, Wang, Chen, Chen, Wu, Hu and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Src activation is related to podocyte mitochondrial apoptosis. (A) JC-1 staining to observe mitochondrial membrane potential changes in podocytes after the indicated treatments. Red fluorescence represents normal, functioning mitochondria while green fluorescence indicates collapsed mitochondrial membrane potential. (Magnification, 200 ×). (B) Flow cytometric detection of podocyte apoptosis rates. (C) MMP measured as the ratio of red to green fluorescence intensity from (A). (D) Quantitation of podocyte apoptosis from (B). (E) Double immunofluorescence labeling of Cyt-c (red) and TOMM20 (green) in podocytes, nuclei labeled with DAPI (blue) (Magnification, 1000 ×). Values are expressed as the mean ± SD, *p < 0.05 vs. NG group, ^# p < 0.05 vs. HG group.