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. 2022 May 9;13:897046. doi: 10.3389/fphar.2022.897046

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Copyright © 2022 Zheng, Wang, Chen, Chen, Wu, Hu and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Silencing of FUNDC1 eliminates the protective effects of PP2 on podocytes exposed to HG conditions. (A) JC-1 staining to detect MMP. (Magnification, 200 ×). (B) MMP measured as the ratio of red to green fluorescence intensity from (A). (C) Flow cytometry analysis of apoptosis in podocytes after the indicated treatments. (D) Quantitation of podocyte apoptosis from (C). Values are expressed as the mean ± SD, *p < 0.05 vs. HG group, ^# p < 0.05 vs. HG + Control siRNA group, ^@ p < 0.05 vs. HG + PP2 group.