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Working model of the molecular mechanism whereby Src inhibits mitophagy under HG conditions to cause podocyte injury. Under HG conditions, the expression and activity of Src are up-regulated in podocytes, leading to increased phosphorylation and inactivation of FUNDC1. In turn, this reduces the recruitment of LC3II to mitochondria and decreases mitophagy. Accumulation of damaged mitochondria in podocytes compromises their function and leads to podocyte apoptosis.
