TABLE 1.
Examples of known neuropsychiatric adverse events from the NeuroDeRisk scope elicited by compounds which bind at the different pLGIC family members.
| Protein family | Ligand | Adverse effects |
|---|---|---|
| GABAARs | Picrotoxin, bicuculline | Seizures |
| Diazepam/benzodiazepines | Amnestic effects, unwanted over-sedation, addiction and many others | |
| Barbiturates, propofol | Addiction | |
| GlyRs | Strychnine, tranexamic acid | Convulsions |
| nAChR | Nicotine | Addiction, insomnia, nausea/vomiting |
| Varenicline | Psychiatric adverse events, seizures, headache, nausea | |
| Mecamylamine | Amnestic effect, negative influence on cognition and learning | |
| 5-HT3Rs | Antiemetics (setrons) | Headache, fatigue, malaise |