TABLE 4.

H/I-induced changes in miRNAs in H/I-insensitive organs with defined target genes.

Organ	H/I regulated miRNAs	Species	Target genes	Functions	References
Liver	Up-regulated by H/I
	miR-210	Human	VMP1	Mediate hypoxia-induced HCC cell metastasis and liver inflammation	Ying et al., 2011; Song et al., 2014
	miR-370	Mouse	TGFBR2	Induce proinflammatory cytokines and hepatic histological damage	Li et al., 2015
	miR-450b-5p	Mouse	CRYAB	Induce inflammatory cytokines and inhibit macrophage M2 polarization	Huang et al., 2020
Down-regulated by H/I
	miR-24-3p	Mouse	STING	Inhibit inflammatory response and apoptosis in hepatic I/R process	Shen et al., 2020
	miR-128-3p	Mouse	Rnd3	Activate NF-κB signaling	Mou et al., 2020
	miR-140-5p	Mouse	CAPN1	Inhibit inflammatory response and apoptosis	Yu et al., 2021
	miR-142-3p	Mouse	MARCKS	Attenuate hepatic I/R injury and inflammation	Li Y. et al., 2020
	miR-146a	Mouse	IRAK1, TRAF6, TLR4	Inhibit proinflammatory cytokines release and apoptosis	Jiang et al., 2014; Chungen et al., 2020
	miR-148a	Mouse	CaMKIIα	Inhibit TLR4-mediated inflammation	Zheng et al., 2018
Muscle	Up-regulated by H/I
	miR-93	Mouse	IRF9	Induce M2-like macrophage polarization in ischemic muscle	Hazarika et al., 2013; Ganta et al., 2017
	miR-155	Human	SOCS-1	Aggravate inflammatory response, leukocyte infiltration and tissue damage	Eisenhardt et al., 2015
Down-regulated by H/I
	miR-92b-3p	Rat	HIF1A	Inhibit inflammatory cytokines	Wang and Quan, 2021
	miR-98	Human	IL6	Modulate inflammation and PASMC apoptosis	Wang Q. et al., 2015
	miR-146b	Mouse	TRAF6	Inhibit inflammatory factors expression	Desjarlais et al., 2019
	miR-let-7a	Human	STAT3	Inhibit inflammation	Cheng et al., 2020

PASMC, pulmonary artery smooth muscle cells.