Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 May 9;9:900978. doi: 10.3389/fcvm.2022.900978

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Gou, Chu, Xiao, Liu, Zhang, Gao and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

scRNA-seq analysis of cardiovascular endothelial cells (ECs) during aging. (A) t-SNE plot showing nine cell types from heart and aorta. CM, cardiomyocyte; MC, mast cell; FB, fibroblast; ENC, endocardial cell; EC, endothelial cell; WBC, leukocyte; RBC, erythrocyte; SMC, smooth muscle cell; Neu, cardiac neuron. (B) Bar plot showing cell proportion of nine cell types from heart and aorta. (C) Violin plots showing expression of EC markers in the heart and aorta. (D) Violin plot showing the SASP gene set score is significantly increased with age in ECs. ns, not significant; **p < 0.01; ***p < 0.001; ****p < 0.0001. (E) t-SNE plot showing eight clusters of ECs from heart and aorta. (F) t-SNE plot showing ECs from heart and aorta across the lifespan. (G) Heatmap showing top 10 markers expressed in each cluster of ECs from the heart and aorta.