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. 2022 May 9;9:900978. doi: 10.3389/fcvm.2022.900978

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Copyright © 2022 Gou, Chu, Xiao, Liu, Zhang, Gao and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in ligand-receptor interactions between cardiovascular ECs and other cell types during aging. (A,B) Changes of selected ligand-receptor interactions between ECs and other cell types (A: ECs express the specific ligand. B: receptor) during aging. CM, cardiomyocyte; MC, mast cell; FB, fibroblast; ENC, endocardial cell; EC, endothelial cell; WBC, leukocyte; RBC, erythrocyte; SMC, smooth muscle cell; Neu, cardiac neuron. Dot size represents the p-value. The color key indicates the mean expression level of each interacting pair.