Table 4.
Volume versus age fit parameters in uncorrected (raw) and corrected (TP correction, ComBat) data.
| Age | Age2 | Age3 | Constant | ||
|---|---|---|---|---|---|
| β (SE) | β (SE) | β (SE) | β (SE) | ||
| Total brain | Raw | −1.15 (0.80) | −0.03 (9.24E−3) | 1354 (14) | |
| TP Correction | −1.46 (0.78) | −0.02 (9.05E−3) | 1346 (14) | ||
| ComBat | −1.91 (0.79) | −0.02 (9.13E−3) | 1368 (14) | ||
| White matter | Raw | 8.64 (1.15) | −0.16 (2.97E−2) | 5.97E−4 (2.25E−4) | 425 (12) |
| TP Correction | 7.45 (1.12) | −0.13 (2.89E−2) | 4.82E−4 (2.19E−4) | 432 (12) | |
| ComBat | 5.84 (1.16) | −0.12 (2.99E−2) | 3.33E−4 (2.26E−4) | 468 (12) | |
| Gray matter | Raw | −10.77 (1.21) | 0.15 (3.13E−2) | −8.07E−4 (2.38E−4) | 938 (13) |
| TP Correction | −10.49 (1.19) | 0.15 (3.08E−2) | −8.13E−4 (2.34E−4) | 929 (13) | |
| ComBat | −10.05 (1.19) | 0.15 (3.08E−2) | −8.11E−4 (2.34E−4) | 921 (13) | |
| Lateral ventricles | Raw | 0.19 (0.15) | −2.53E−3 (3.76E−3) | 5.4E−5 (2.90E−5) | 6.24 (1.56) |
| TP Correction | 0.18 (0.14) | −2.38E−3 (3.72E−3) | 5.3E−5 (2.80E−5) | 6.16 (1.54) | |
| ComBat | 0.14 (0.14) | −5.48E−4 (3.65E−3) | 3.6E−5 (2.80E−5) | 6.34 (1.52) | |
| Thalamus | Raw | −1.26E−2 (1.96E−2) | −8.73E−4 (5.07E−4) | 5.00E−6 (4.00E−6) | 13.64 (0.21) |
| TP Correction | 1.70E−3 (1.89E−2) | −9.93E−4 (4.89E−4) | 5.00E−6 (4.00E−6) | 13.30 (0.20) | |
| ComBat | −1.60E−2 (1.90E−2) | −6.59E−4 (4.91E−4) | 3.00E−6 (4.00E−6) | 13.59 (0.20) | |
| Caudate | Raw | −5.78E−2 (1.60E−2) | 5.66E−4 (4.13E−4) | −3.00E−6 (3.00E−6) | 8.87 (0.17) |
| TP Correction | −5.43E−2 (1.60E−2) | 5.26E−4 (4.13E−4) | −3.00E−6 (3.00E−6) | 8.80 (0.17) | |
| ComBat | −5.61E−2 (1.60E−2) | 5.66E−4 (4.14E−4) | −3.00E−6 (3.00E−6) | 8.81 (0.17) | |
| Putamen | Raw | −3.77E−2 (1.45E−3) | 10.09 (0.06) | ||
| TP Correction | −3.76E−2 (1.45E−3) | 10.08 (0.06) | |||
| ComBat | −3.71E−2 (1.44E−3) | 10.07 (0.06) | |||
| Globus pallidus | Raw | −1.76E−2 (5.02E−3) | 1.87E−4 (1.30E−4) | −8.85E−7 (9.84E−7) | 2.76 (0.05) |
| TP Correction | −1.53E−2 (5.05E−3) | 1.50E−4 (1.30E−4) | −7.05E−7 (9.89E−7) | 2.73 (0.05) | |
| ComBat | −1.66E−2 (5.02E−3) | 1.81E−4 (1.30E−4) | −9.0E−7 (9.84E−7) | 2.73 (0.05) |
Significant differences in Z tests between TP -corrected or ComBat corrected parameters (vs. uncorrected) are shown in bold (p < 0.05). TP, Traveling Phantom.