Fig. 5.

The Cu release from nHA particles and nHA/Cs/Gel scaffolds. The analysis of Cu release from nanoparticles and scaffolds in different time intervals evidenced the sustained Cu release starting with the initial rapid release in the first week. (A) Dropping Cu release was remarked in nHA.Cu3% and nHA.Cu7% after 14 and 7 days respectively but nHA.Cu5% sample held on to slowly enhanced release. Significant levels of ion release indicated by letters were observed in nHA.Cu7% (days 3 and 7) and all groups (days 10-21) (c: P value < 0.001); (B) Scaffolds made a peak release of Cu ions from days 7 to 10 followed by gradually declined release. Significant differences were tracked in all groups (day 7) and nHA.Cu5% (days 3, 10 and 14) (c: P value < 0.001).