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Schematic diagram depicting critical roles of Axin2+ progenitor cells and their progeny in orthodontic tension–induced new bone formation. Upon the stimulation of tension force, the quiescent Axin2+ periodontal ligament (PDL) cells (as a key progenitor cell source) became mitotically active and directly differentiated into osteoblasts (expressing RUNX2); they then became osteocytes (expressing DMP1), contributing to the new bone formation on the tension side.
