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. 2022 May 9;12:824354. doi: 10.3389/fonc.2022.824354

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Copyright © 2022 Liu, Wang, Guo, Shao, Li, Zhou, Zhao, Xue, Feng, Li, Tan, Zhang, Xue, Gao, Gao and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional enrichment and gene co-expression network analysis. (A) Top 12 significantly enriched GO terms (FDR < 0.001, count >10) ranked by gene ratio in BP (top 4 items), CC (middle 5 items), and MF (bottom 2 items) of 143 upregulated genes in platelets of the ESCC group compared to the control group. (B) Enriched GO terms (FDR < 0.2) of 80 downregulated genes in platelets of the ESCC group compared to the control group. All the enriched GO terms belonged to MF. (C) Enriched KEGG terms (FDR < 0.05) of 143 upregulated genes in platelets of the ESCC group compared to the control group. (D) Two hundred and twenty-three DEGs imported to String to generate a gene co-expression network containing 132 nodes and 281 wedges. Red-colored dots indicated 85 upregulated genes and blue-colored dots indicated 47 downregulated genes. Red square indicated hub genes (FN1, ACTB, and MYC) with highest values of degree. (E) Top 15 hub genes ranked by degree (>12) in Cystoscope were highly clustered and centered among FN1, ACTB, and MYC. BP, biological process; CC, cellular component; DEGs, differentially expressed genes; ESCC, esophageal squamous cell carcinoma; FDR, false discovery rate; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; MF, molecular function.