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. 2022 May 9;12:868363. doi: 10.3389/fonc.2022.868363

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Copyright © 2022 Wang, Qian, Cao, Xu, Jin, Hu, Fu, Li, Wang, Wang, Xia and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of functional circRNAs in various types of cancer. The map shows the circRNAs that have been confirmed to function in various types of cancer. As the mechanism of drug resistance is complex, only the main mechanism is listed in this map. Among the number other mechanisms, specific mechanisms such as the regulation of metabolism, cell cycle, apoptosis, RNA binding proteins (RBPs), immune escape,etc, summed up as alterations in target gene copy number and the activation of bypass pathways or downstream signaling.