Table 2.
Nirmatrelvir-Related Clinical Pathology Findings in 1-Month Rat Toxicity Study.
| Sex | Endpoint | Vehicle (Mean ± SD [n]) | 60 mg/kg (q.d.) (Mean ± SD [n]) | 200 mg/kg (q.d.) (Mean ± SD [n]) | 1,000 mg/kg (q.d.) (Mean ± SD [n]) |
|---|---|---|---|---|---|
| Male | Platelet count (1 × 103/μL) | 836.1 ± 58.8 (9) | 940.0 ± 90.8* (10) | 967.2 ± 115.4a,* (10) | 1073.1 ± 135.0a,b (10) |
| Prothrombin time (s) | 13.02 ± 0.43 (10) | 13.66 ± 0.71* (10) | 13.84 ± 0.69a,* (10) | 14.92 ± 0.61a,b (10) | |
| Female | Platelet count (1 × 103/μL) | 1007.0 ± 124.9 (10) | 1026.9 ± 129.6 (9) | 1126.6 ± 123.2a (10) | 1174.7 ± 110.6a,* (10) |
| Prothrombin time (s) | 11.94 ± 0.61 (10) | 12.22 ± 0.93 (9) | 12.37 ± 0.57 (10) | 12.62 ± 0.94a (10) |
Samples collected on day 29.
aDenotes nirmatrelvir-related findings.
bp<0.01 following a pairwise comparison.
Statistical analysis;*P < 0.05 following a pairwise comparison.