Table 3.
Effect of Nirmatrelvir on Body, Liver, and Heart Weight in 2-Week and 1-Month Rat Toxicity Studies.
| Sex | Duration | Weight (g) | Vehicle (Mean ± SD [n]) | MTBE control (Mean ± SD [n]) | 60 mg/kg (q.d.) (Mean ± SD [n]) | 200 mg/kg (q.d.) (Mean ± SD [n]) | 1,000 mg/kg (q.d.) (Mean ± SD [n]) |
|---|---|---|---|---|---|---|---|
| Male | 2-week | Total body | 281.29 ± 26.78 (10) | 280.92 ± 23.43 (10) | 277.48 ± 16.74 (10) | 278.58 ± 29.18 (10) | 281.48 ± 35.28 (10) |
| Liver | 7.95 ± 0.74 (10) | 8.17 ± 0.75 (10) | 8.13 ± 0.71 (10) | 8.68 ± 1.11d (10) | 10.78 ± 1.73a,c (10) | ||
| Heart | 0.92 ± 0.12 (10) | 0.94 ± 0.09 (10) | 0.90 ± 0.11 (10) | 0.91 ± 0.12 (10) | 0.90 ± 0.11 (10) | ||
| Female | 2-week | Total body | 185.49 ± 11.91 (10) | 178.25 ± 11.11 (10) | 172.68 ± 16.11 (10) | 178.20 ± 10.65 (10) | 191.11 ± 14.41 (10) |
| Liver | 5.22 ± 0.45 (10) | 4.93 ± 0.42 (10) | 4.96 ± 0.62d (10) | 5.57 ± 0.43d,b (10) | 8.30 ± 0.96a,c (10) | ||
| Heart | 0.70 ± 0.04 (10) | 0.67 ± 0.10 (10) | 0.65 ± 0.07e,b (10) | 0.64 ± 0.06e,b (10) | 0.62 ± 0.08*,b (10) | ||
| Male | 1-month | Total body | 325.48 ± 21.57 (10) | –– | 320.15 ± 30.82 (10) | 320.55 ± 18.23 (10) | 314.97 ± 20.42 (10) |
| Liver | 7.73 ± 0.49(10) | –– | 8.28 ± 1.41d (10) | 8.80 ± 0.64a,d,c (10) | 11.49 ± 0.96a,c (10) | ||
| Heart | 0.93 ± 0.08 (10) | –– | 0.91 ± 0.09 (10) | 0.92 ± 0.09 (10) | 0.88 ± 0.09 (10) | ||
| Female | 1-month | Total body | 195.41 ± 13.67 (10) | –– | 194.47 ± 16.00 (10) | 201.98 ± 19.48 (10) | 204.85 ± 13.65 (10) |
| Liver | 4.90 ± 0.42 (10) | –– | 5.24 ± 0.54d,b (10) | 6.10 ± 0.68a,d,c (10) | 8.98 ± 0.96a,c (10) | ||
| Heart | 0.67 ± 0.07 (10) | –– | 0.66 ± 0.09 (10) | 0.73 ± 0.06 (10) | 0.66 ± 0.08 (10) |
SD, Standard Deviation; n, number of individual animals.
ap<0.01 following a pairwise comparison.
bp<0.05 denotes a statistically significant trend.
cp<0.01 denotes a statistically significant trend.
ddenotes and ascending trend.
edenotes a descending trend.
Statistical analysis;*P < 0.05 following a pairwise comparison.