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. 2022 May 9;15:895429. doi: 10.3389/fnmol.2022.895429

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Copyright © 2022 Hussain, Fang, Huang, Feng, Yao, Wang and Chang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GSK-3β inhibitor-induced activation of β-catenin signaling regulates the expression of transcytosis-related genes in brain endothelial cells. bEnd.3 cells were incubated with LiCl (0, 5, 10, and 20 mM) for 24 h and then subjected to various measurements. (A–D) qRT-PCR measurement of the mRNA levels of Axin2, Mfsd2a, Cav-1, and Plvap normalized with that of β-actin. (E) Western blot measurement of β-catenin, Mfsd2a, Cav-1, and Plvap. (F–I) Relative protein levels of β-catenin, Mfsd2a, Cav-1, and Plvap normalized with that of GAPDH. Data are mean ± SD. n = 3 per group. ns = not significant, P > 0.05, *P ≤ 0.05, ^**P ≤ 0.01, ^***P ≤ 0.001, ^****P ≤ 0.0001.