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. 2022 May 9;12:851003. doi: 10.3389/fonc.2022.851003

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Copyright © 2022 Costa Junior, Teixeira Júnior, Rocha, Sobrinho, Barbosa, Silva, Corrêa, Alencar Junior, Nascimento, Melo, Calixto and Silva

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathological and immunohistochemical aspects of leiomyosarcoma of the penis: spindle cell malignant neoplasm with a high number of mitoses (white arrow) and atypical mitoses (black arrow) (A); the neoplasm was negative for epithelial markers: epithelial membrane antigen (B) and pan-cytokeratin (C); the immunohistochemical expression was strong and diffuse for smooth muscle markers: alpha-smooth muscle actin (D) and calponin (E); the neoplasm is also negative expression for: p16 (F), S100 (G) and CD34 (H).