TABLE 3.

Anti-inflammatory activity (% inhibition of COX-2) in aqueous and ethanolic extracts of the studied tunicates and sea cucumber species.

	Anti-inflammatory activity (% inhibition COX-2)
	Extract
Species	Aqueous (n = 4)	Ethanolic (n = 4)
Styela plicata	19.6 ± 5.8cA	76.7 ± 3.4cB
Aplidium sp.	27.8 ± 2.5dA	70.2 ± 6.3cB
Botrylloides diegensis	8.9 ± 3.7bA	75.9 ± 3.0cB
Ciona robusta	33.2 ± 5.2dA	92.2 ± 8.5dB
H. (Roweothuria) arguinensis	ndaA	40.0 ± 7.6bB
H. (Holothuria) mammata	ndaA	41.8 ± 4.9bB
H. (Panningothuria) forskali	ndaA	16.4 ± 9.7aB

Values are presented as average ± standard deviation. nd, not detected. For all groups, n = 4. Different lowercase letters within a column correspond to statistical differences (p < 0.05) between different species within same type of extract. Different uppercase letters within a row correspond to statistical differences (p < 0.05) between aqueous and ethanolic extracts from the same species.