Table 2.
Correlation between proteasome 20S α+β expression and clinicopathologic characteristics in 90 CRC patients.
| Variables | Proteasome 20S α+β expression | |||
|---|---|---|---|---|
| Total | Low | High | P value | |
| Gender | 0.432 | |||
| Male | 42 | 32 (76.2%) | 10 (23.8%) | |
| Female | 48 | 33 (68.8%) | 15 (31.2%) | |
| Age (years) | 0.595 | |||
| ≤60 | 29 | 22 (75.9%) | 7 (24.1%) | |
| >60 | 61 | 43 (70.5%) | 18 (29.5%) | |
| Size | 0.001∗∗∗ | |||
| ≤5 cm | 43 | 38 (88.4%) | 5 (11.6%) | |
| >5 cm | 47 | 27 (57.4%) | 20 (42.6%) | |
| Depth of invasion | 0.457 | |||
| ≤pT2 | 13 | 11 (84.6%) | 2 (15.4%) | |
| ≥pT3 | 77 | 54 (70.1%) | 23 (29.9%) | |
| Lymph node metastasis | 0.002∗∗ | |||
| No | 59 | 49 (83.1%) | 10 (16.9%) | |
| Yes | 31 | 16 (51.6%) | 15 (48.4%) | |
| Distant metastasis | 0.030∗ | |||
| No metastasis | 85 | 64 (75.3%) | 21 (24.7%) | |
| Metastasis | 5 | 1 (20.0%) | 4 (80.0%) | |
| Localization | 0.367 | |||
| Proximal colon | 14 | 12 (85.7%) | 2 (14.3%) | |
| Distal colon | 76 | 53 (69.7%) | 23 (30.3%) | |
| TNM stage | ≤0.01 | |||
| I and II | 57 | 49 (86.0%) | 8 (14.0%) | |
| III and IV | 33 | 16 (48.5%) | 17 (51.5%) | |
| Histological grade | 0.140 | |||
| Well | 6 | 5 (83.3%) | 1 (16.7%) | |
| Moderately | 70 | 53 (75.7%) | 17 (24.3%) | |
| Poorly | 14 | 7 (50.0%) | 7 (50.0%) | |
| CEA (μg/L) | ≤0.01 | |||
| ≥5 | 54 | 47 (87.0%) | 7 (13.0%) | |
| <5 | 36 | 18 (72.2%) | 18 (27.8%) | |
| pSTAT3 | ≤0.01 | |||
| Low | 57 | 51 (89.47%) | 6 (10.53%) | |
| High | 33 | 14 (42.42%) | 19 (57.58%) | |
∗ P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001.