Table 3.
Univariate and multivariate Cox regression analyses of overall survival in 90 CRC patients.
| Variables | Univariate analysis (Cox: enter) | Multivariate analysis (Cox: forward conditional) | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | P | |
| Gender | ||||||
| Male versus female | 0.770 | 0.389–1.526 | 0.454 | |||
| Age (years) | ||||||
| ≤60 versus >60 | 1.200 | 0.574–2.511 | 0.628 | |||
| Size (cm) | ||||||
| ≤5 versus >5 | 3.471 | 1.616–7.456 | 0.001 | |||
| Depth of invasion | ||||||
| ≤pT2 versus ≥pT3 | 1.945 | 0.594–6.365 | 0.271 | |||
| Lymph node metastasis | ||||||
| No versus yes | 3.197 | 1.619–6.310 | 0.001 | |||
| Distant metastasis | ||||||
| No metastasis versus metastasis | 2.841 | 0.996–8.105 | 0.051 | |||
| Localization | ||||||
| Proximal versus distal | 1.131 | 0.438–2.922 | 0.799 | |||
| Histological grade | ||||||
| Well and moderate versus poor | 2.824 | 1.385–5.760 | 0.004 | |||
| TNM stage | ||||||
| I and II versus III and IV | 3.866 | 1.927–7.758 | ≤0.01 | 2.423 | 1.093–5.376 | 0.029 |
| CEA | ||||||
| ≥5 versus <5 | 1.081 | 0.546–2.141 | 0.823 | |||
| pSTAT3 | ||||||
| Low versus high | 2.762 | 1.397–5.458 | 0.003 | |||
| Proteasome 20S α+β | ||||||
| Low versus high | 5.335 | 2.679–10.624 | ≤0.01 | 4.214 | 2.058–8.628 | ≤0.01 |
HR: hazard ratio; 95% CI: 95% confidence interval.