Table 1.
Sample characteristics.
| RUN DMC – InTENse sub-study n = 52 | RUN DMC main study n = 105 | p-value | |
|---|---|---|---|
| Demographic characteristics | |||
| Age [years], median (IQR) | 68.50 (8.25) | 77.15 (8.19) | <0.0001 |
| Female, n (%) | 18 (35) | 48 (46) | 0.2484 |
| Vascular risk factors, n (%) | |||
| Hypertension | 43 (83) | 75 (72)a | 0.2102 |
| Hypercholesterolemia | 25 (50) | 62 (60)a | 0.3318 |
| Diabetes | 6 (12) | 16 (15)a | 0.6843 |
| Current or past smoking | 37 (71) | 72 (69) | 0.8835 |
| Clinical scores, median (IQR) | |||
| Processing speed z-score | −0.15 (1.16) | −0.18 (1.55) | 0.6265 |
| Barthel scale score | 100 (5) | 100 (5)a | 0.8930 |
| SVD imaging markers, median (IQR) | |||
| WMH volumeb [%] | 0.35 (0.59) | 0.31 (0.74) | 0.7984 |
| Lacune count | 0 (0) | 0 (1) | 0.3648 |
| Microbleed count | 0 (1) | 0 (1) | 0.8816 |
| Brain volumeb [%] | 77.73 (5.35) | 72.51 (4.79) | <0.0001 |
IQR= interquartile range; WMH = white matter hyperintensity.
aBased on n = 104 due to missing data for one patient.
bNormalized by intracranial volume.