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. 2021 Dec 15;42(6):952–965. doi: 10.1177/0271678X211067133

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© The Author(s) 2021

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Figure 1. — Transcriptic-metabolic jointomics analysis of peripheral CD4⁺ T cells from CD4 ^cre ACC1 ^fl/fl mice stroke mice. A: Schematic representation of the experimental design. B: Differentially expressed genes (DEGs) displayed on a volcano plot. Red and blue spots represent genes whose expression was significantly changed between the CD4⁺ T cells from CD4 ^cre ACC1 ^fl/fl and ACC1 ^fl/fl mice after MCAO. Gray spots represent genes without significant changes. C: KEGG pathway enrichment analysis results for all DEGs. D: Relative gene expression of fatty acid metabolism related enzymes. E: Different metabolites were detected in metabolomics between the CD4⁺ T cells from CD4 ^cre ACC1 ^fl/fl and ACC1 ^fl/fl mice after MCAO. F: KEGG analysis of the significantly altered the metabolites.

MCAO: middle cerebral artery occlusion; ACC1: acetyl coenzyme A carboxylase 1; DEG: differentially expressed gene; KEGG: Kyoto Encyclopedia of Genes and Genomes.