Figure 6.

Neutralization of RAGE improves long‐term functional recovery of MCAO mice. A‐C: Sensorimotor dysfunction was significantly attenuated in sRAGE‐treated mice after MCAO, as assessed by the Garcia Score (A), adhesive removal (B) and grid walk (C) test. A: sRAGE‐treated mice demonstrated improved scores in body proprioception, lateral turning, and total assessment. B–C: Less sensorimotor deficits were observed in the sRAGE group as reflected by shorter contact and removal time of the sticker and less forelimb foot fault. Data are expressed as mean±SD. *P ≤ 0.05, vs PBS. Two‐way repeated measures ANOVA for differences between groups. n = 9–10 per group.