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. Author manuscript; available in PMC: 2022 May 23.
Published in final edited form as: J Med Chem. 2021 Jan 5;64(1):741–767. doi: 10.1021/acs.jmedchem.0c01735

Figure 10:

Figure 10:

In vivo uptake of PS 16 at a dose of 0.47μmole/kg in tumor, liver and skin of SCID mice bearing (A) UMUC3 and (B) FaDu tumors. The in vivo PDT efficacy (long-term tumor response) of PS 16 at a dose of 0.47 μmole/kg and PS 16 for UMUC 3 and FaDu tumors are shown Figures C and D respectively. The tumors were exposed to light (665 nm, 135J/cm2, 75 mW/cm2) at 24 h post-injection of the PS. A direct correlation between the PS uptake and tumor response (cure) was observed./kg. Statistical analysis log rank (Mantel-Cox test), (C) UMUC3, p-value: <0.0001 and (D) FaDu tumors, p-value: 0.0019. For PS-uptake study (tumor, liver and skin), 3 female SCID mice bearing either UMUC3 or FaDu tumors were used (Figures 9A & 9B). For determining in-vivo efficacy the number of female SCID mice used in each study are indicated in the Figure 9C & 9D.