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. Author manuscript; available in PMC: 2022 May 23.
Published in final edited form as: J Med Chem. 2021 Jan 5;64(1):741–767. doi: 10.1021/acs.jmedchem.0c01735

Figure 8:

Figure 8:

In vivo uptake of PS 10 at the dose of 0.47, 0.25 and 0.125 μmole/kg and HPPH in tumor, liver and skin of SCID mice bearing FaDu tumors (3 mice/group), is shown in A, B, C and D respectively. The in vivo PDT efficacy (long-term tumor response) of PS 10 at variable doses: 0.47, 0.25 and 0.125 μmole/kg and HPPH at a dose of 0.47 μmole/kg is shown in Figure 8E. Tumors were exposed to light (665 nm, 135 J/cm2, 75 mW/ cm2) at 24h post injection and tumor-growth was measured daily for 60 days. For PS-uptake study (tumor, liver and skin), 3 female SCID mice bearing FaDu tumors were used (Figures 8A-8D). For determining in-vivo efficacy, the number of female SCID mice used in each study are indicated in the Figure 8E). Statistical analysis; log rank (Mantel-Cox test), p-value:<0.0001.