Table 1:

Comparative in vitro photosensitizing efficacy (IC₅₀) of PS-erlotinib conjugates with HPPH in UMUC3 (bladder cancer) and FaDu (head & neck cancer) cell lines.

In Vitro PDT Efficacy (IC50) of photosensitizers (concentration: nM)
Compound #	UMUC3	FaDu	Compound #	UMUC3	FaDu	Compound #	UMUC3	FaDu
5	20.25	17.6	17	34.4	59.6	42	6.8	15.4
7	187.4	519.8	19	76.3	23.3	43	7.5	21.4
8	43.4	-	22	195.9	1,246	49	26.4	19.2
10	59.4	35.5	23	-	>10 μM	50	59.2	88.6
11	54.8	31.8	31	-	6,925	53	45.0	166.2
13	16.8	-	35	28.2*	13.8	HPPH	68.4	43.8
14	*8.9	-	37	39.6	33.42
16	20.9	59.6	38	3.502	-