Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 May 10;29(5):409–424. doi: 10.1089/cmb.2021.0316

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright 2022, Mary Ann Liebert, Inc., publishers

PMC Copyright notice

FIG. 4. — Histone mark profiles for subsets of genes expressed at high levels, intermediate levels, and low levels. (a) For GM12878, the average histone mark profile for the top 100 genes by expression level is dominated by H3K4me3 as would be expected for actively transcribed genes. The histone mark profile for genes at intermediate expression value is characterized by high importance scores for H3K4me3 and H3K27me3, which is correlated with a bivalent/poised TSS. Lastly, the histone mark profile for genes with low expression shows that the H3K27me3 signal is most important, which is associated with repression. Similar patterns can be observed for (b) K562 and (c) HUVEC. TSS, transcription start site.