Table 1.

12-Step desensitization protocol with 1695 mg Ifosfamide + 1695 mg Mesna

Domiciliary Allergy premedication (Start 2 days before)	- Singulair 10 mg
	- Aspirine 300 mg
	- Ebastine 10 mg
	- Ranitidine 150 mg
Hospital Oncology premedication	- Dexamathasone 8 mg intravenous
	- Ganisetron 1 mg oral
Hospital Allergy premedication	- Polaramine 1 vial intravenous
	- Ranitidine 50 mg intravenous
	- Diazepam 5 mg sublingual

3 dilutions of the total doses with 1000 ml 0.9% NaCl	Total doses	mg/ml
Solution 1/100	16.95	0.01695
Solution 1/10	169.5	0.1695
Solution 1/1*	1691.665	1.691665

	Rate (ml/h)	Time (min)	Vol. Infused (ml)	Doses (mg)
Solution 1/100	2	15	0.5	0.008
	5	15	1.25	0.021
	10	15	2.5	0.042
	20	15	5	0.085
	Total =	60	9.25	0.157
Solution 1/10	5	15	1.25	0.212
	10	15	2.5	0.424
	20	15	5	0.848
	40	15	10	1.695
	Total =	60	18.75	3.178
Solution 1/1	10	15	2.5	4.238
	20	15	5	8.475
	40	15	10	16.950
	80	15	20	33.900
	132**	437	960.53	1628.103
	Total =	617	1000	1691.665
			Total mg	1695

*In this solution we take into acount the previous doses administered in Solution 1/100 and 1/10, which are subtracted from this solution

**Variation of the protocol adding a 13 step