Table 2.

Current Pediatric CAR-T Cell Therapy Clinical Trials

Antigen target	Cellular product	Key inclusion	NCT number
GD2	CAR-T	H3K27M-mutant diffuse intrinsic pontine glioma (DIPG) or spinal H3K27M-mutant diffuse midline glioma (DMG)	NCT04196413
GD2	CAR-T + C7R	high grade glioma (HGG) or diffuse intrinsic pontine glioma (DIPG) or medulloblastoma or another rare brain cancer that expresses GD2	NCT04099797
B7-H3	CAR-T	CNS disease for which there is no standard therapy, or diagnosis of DIPG or DMG at any time point following completion of standard therapy	NCT04185038
IL-13Ra2	CAR-T	Recurrent/Refractory Malignant Brain Tumors	NCT04510051
Her2	CAR-T	recurrent or refractory HER2-positive CNS tumors	NCT03500991
Her2	CAR-T	progressive recurrent or refractory HER2-positive primary central nervous system (CNS) tumor or HER2 positive tumor metastatic to the CNS	NCT02442297
EGFR 806	CAR-T	children and young adults with recurrent or refractory EGFR-positive CNS tumors	NCT03638167