Figure 1.

Crystal structure of apo-nsp14

(A) Arrangement of the molecules in the asymmetric unit. Model (A) blue and model (B) pink. MTase and ExoN domains within the bimodular structure of nsp14 are distinguished by a primary color shade. Active-sites residues are indicated in red in one molecule, and the detailed arrangements of the active sites are shown in inserts.

(B) Interactions of SAH (orange, stick model) at the active site of nsp14 MTase domain (pink, ribbon). Hydrogen bonds are depicted as dotted lines; waters are indicated as red spheres.

See also Figure S1.