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. 2022 May 23;20:240. doi: 10.1186/s12951-022-01441-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — In vitro and in vivo photothermal effect of MPG NPs. A Temperature changes of different concentrations of Mn₃O₄@PEG after 5 min of laser irradiation. B Temperature change of Mn₃O₄@PEG after 5 min of laser irradiation with different powers. C Temperature change of the same concentration of Mn₃O₄@PEG, PDA and MPG NPs after 5 min of laser irradiation. D Temperature change of MPG NPs after 5 min of laser irradiation with different powers. E Temperature change of different concentrations of MPG NPs after 5 min of laser irradiation. F Temperature change of MPG with or without laser irradiation. G Temperature changes under laser irradiation after 6 h of in vivo injection of MPG NPs. H Schematic diagram of the photothermal effect of MPG NPs under laser irradiation after endocytosis