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Embryonic development of mouse SMGs. Gland initiation starts around E11.5, with an epithelial thickening growing into a condensing neural crest-derived mesenchyme. Epithelial cells are pluripotent and undergo branching morphogenesis from ∼E13. Lineage restriction occurs once differentiation starts between E15 and E16, although branching morphogenesis continues and secretory and MEC differentiation begin. See glossary for abbreviations.
