FIGURE 8.

Models of epithelial lineage relationships during homeostasis and in models of damage. A and B: epithelial lineages are self-restricted, and cell types regenerate themselves during homeostasis (A) and mild reversible ligation injury (B). During severe ligation injury, cell plasticity of multiple populations becomes evident, particularly MECs and duct cells, which can regenerate all cell types, including acinar cells. C: after IR damage, duct cells can partially differentiate into acinar cells. See glossary for abbreviations. Created with BioRender.com, with permission.