Table 4.
Annotation of overlapping genes of placenta DMGs and DEGs
| Gene | Delta | log2FC | Pathway |
|---|---|---|---|
| ADCY5 | 0.5 | 1.93 | Ovarian steroidogenesis |
| Cortisol synthesis and secretion | |||
| Insulin secretion | |||
| Bile secretion | |||
| B3GALT5 | 0.12 | − 1.64 | Glycosphingolipid biosynthesis—globo and isoglobo series |
| GADD45A | − 0.25 | − 1.5 | p53 signaling pathway |
| Chronic myeloid leukemia | |||
| HK2 | − 0.67 | − 2.92 | Insulin signaling pathway |
| Type II diabetes mellitus | |||
| Fructose and mannose metabolism | |||
| JAG2 | 0.25 | 1.81 | Endocrine resistance |
| LDLR | − 0.63 | 1.31 | Cortisol synthesis and secretion |
| Aldosterone synthesis and secretion | |||
| Bile secretion | |||
| PLA2G4A | 0.4 | − 1.25 | Glutamatergic synapse |
| Ovarian steroidogenesis | |||
| Oxytocin signaling pathway | |||
| RYR2 | − 0.12 | 1.86 | Insulin secretion |
| Oxytocin signaling pathway | |||
| Dilated cardiomyopathy] | |||
| SH2B2 | 0.49 | 1.43 | Insulin signaling pathway |
| SOCS3 | − 0.5 | − 1.04 | Growth hormone synthesis, secretion and action |
| Insulin signaling pathway | |||
| Type II diabetes mellitus |
delta DNA methylation difference, log2FC log2(Fold Change), Pathway KEGG pathway annotation