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. 2022 May 9;13:842576. doi: 10.3389/fimmu.2022.842576

Table 4.

Modified glycosides (61-68) and polyketides (69-72) with antivenom properties.

Compound Plant Activity inhibited Venom or toxin Snake Reference
61 2-(6-benzoyl-β-glucopyranosyloxy)-7-(1α,2α,6α -trihydroxy-5-oxocyclohex-3-enoyl)-5-hydroxybenzyl alcohol Bennettiodendron leprosipesB, Flacourtia ramontchiBC enzimatic PDE-I - (111)
62 homaloside D B. leprosipesB, F. ramontchiBC enzimatic PDE-I - (111)
63 itoside B Itoa orientalisB enzimatic PDE-I - (111)
64 itoside F I. orientalisB,BC enzimatic PDE-I - (111)
65 scolochinenoside C S. chinensisS enzimatic PDE-I - (110)
66 scoloposide C S. chinensisS enzimatic PDE-I - (110)
67 benzoylsalireposide Symplocos racemosaWP enzimatic PDE-I - (147)
68 salireposide S. racemosaWP enzimatic PDE-I - (147)
69 lapachol - enzimatic Venom B. jararaca, B. atrox (180)
69a analogue of lapachol - enzimatic Venom B. jararaca, B. atrox (180)
70 isohemigossypolone Pachira aquaticaR injury Venom B. pauloensis, B. moojeni (149)
71 ehretianone Ehretia buxifoliaSB morthality Venom E. carinatus (86)
72 melanin Thea sinensis Linn.BT enzimatic Venom, PLA2 A. contortrix laticinctus, A. halys blomhoffii, C. atrox (150)

SB, stem bark; R, roots; S, stem; WP, whole plant; B, bark; BC, branches; BT, black tea; Phosphodiesterase I, PDE-I; Phospholipase A2, PLA2.