Table 1:
Male | Female | Lactation | ||||
---|---|---|---|---|---|---|
Control | TβRII ocy−/− | Control | TβRII ocy−/− | Control | TβRII ocy−/− | |
Distal Femur | ||||||
Tb.BV/TV(%) | 0.18 ± 0.04 | 0.30 ± 0.07* | 0.08 ± 0.04 | 0.1 ± 0.05 | 0.04 ± 0.01a | 0.08 ± 0.02b |
Tb.N (1/mm) | 5.30 ± 1.08 | 6.11 ± 0.87 | 2.44 ± 0.72 | 2.68 ± 1.13 | 1.76 ± 0.45 | 2.89 ± 0.84 |
Tb. Th (mm) | 0.03 ± 0.003 | 0.05 ± 0.01* | 0.033 ± 0.01 | 0.035 ± 0.01 | 0.022 ± 0.002 a | 0.027 ± 0.00a,b,c |
Tb. Sp (mm) | 0.16 ± 0.05 | 0.12 ± 0.03* | 0.40 ± 0.12 | 0.42 ± 0.22 | 0.59 ± 0.2 a | 0.35 ± 0.15 b,c |
SMI | 1.71 ± 0.36 | 0.52 ± 0.62* | 2.83 ± 0.43 | 2.74 ± 0.66 | 3.01 ± 0.27 | 2.48 ± 0.38 |
Tb. Min (mg HA/cm3) | 1065.5 ± 18.9 | 1098.3 ± 16.3* | 1103.85 ± 30.2 | 1096.5 ± 23.6 | 1010.5 ± 27.0a | 1035.3 ± 40.9c |
Midshaft Femur | ||||||
Ct. BA/TA(%) | 0.28 ± 0.03 | 0.30 ± 0.03 | 0.28 ± 0.02 | 0.29 ± 0.02 | 0.21 ± 0.03a | 0.24 ± 0.02a,b,c |
Ct. Th(mm) | 0.20 ± 0.01 | 0.22 ± 0.02* | 0.19 ± 0.01 | 0.20 ± 0.01 | 0.14 ± 0.006a | 0.16 ± 0.007c |
Ct. SMI | 0.16 ± 0.41 | 2.82 ± 1.42* | 0.28 ± 0.14 | 0.12 ± 0.23 | 0.22 ± 0.03 | 0.10 ± 0.18 |
Ct. Min (mg HA/cm3) | 1385.8 ± 14.4 | 1337.8 ± 18.7* | 1362.60 ± 46.6 | 1332.5 ± 66.4 | 1330.3 ± 29.1 | 1319.2 ± 36.5 |
p<0.05 significantly different from the male control virgin (Student’s t-test),
p<0.05 significantly different from the control virgin,
p<0.05 significantly different from the control lactation, and
p<0.05 significantly different from the virgin TβRIIocy−/− mice.