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. 2022 May 23;18(5):e1010209. doi: 10.1371/journal.pgen.1010209

Fig 1. Isolation of a mutant in the PRC1 factor MIG-32 that affects the fate of the AIY neuron.

Fig 1

(A) Gene regulatory network that initiates and maintains the type-specific identity of the AIY neuron. (B) Percentage of L4 larvae that display a loss of ttx-3pB::gfp (otIs173) expression in one (grey bar) or two (black bar) AIY neurons (error bars show standard error of proportion, numbers above the bars show number of animals analyzed). mig-32; spat-3 double mutants are not statistically different from mig-32 or spat-3 single mutants (Fisher’s exact test, p>0.05). (C) Alignment of the RING finger and downstream region of MIG-32 with orthologs of the arthropod Drosophila melanogaster (Dm), the platyhelminth Schistosoma japonicum (Sj), the vertebrate Homo sapiens (Hs) and the echinoderm Strongylocentrotus purpuratus (Sp). The amino acids of the RING finger that bind Zn2+ are highlighted in blue. The two mutations present in mig-32(vba19vba20) are highlighted in red.