FIGURE 2.

Dynamic change of variant allele frequency (VAF) with serial next‐generation sequencing (NGS) assessments. (A) Comparison of VAFs at diagnosis and remission in 15 patients with diagnosis‐remission paired samples. (B) Comparison of VAFs at remission and relapse in 18 patients with remission‐relapse paired samples. (C) Comparison of VAFs at three different relapse stages in 24 relapsed patients, including very early, early and late relapse stage. Each point in different color represents an independent VAF mutation site. VAF, variant allele frequency; NGS, next‐generation sequencing