FIGURE 3.

Relapse‐related clonal evolution patterns based on variant allele frequency (VAF). (A) Schematic diagram of three relapse‐related clonal evolution patterns, including relapse evolution from a genetically distinct clone, a major clone at diagnosis, and a subclone at diagnosis, named clonal evolution patterns A, B and C, respectively. Longitudinal analysis of VAF (B) and relapse‐related clonal evolution pattern (C) in three representative pediatric B‐ALL patients. The horizontal axis represents follow‐up time, and the vertical axis indicates VAF. Each point in different color represents an independent VAF mutation site. VAF, variant allele frequency; BM, bone marrow