Table 1.
Power for comparison of each Diabetes Prevention Program modality vs usual carea
| Observed weight lossc | Observed HbA1c decreased | |||||
|---|---|---|---|---|---|---|
| Enrollmentb | UC | DPP | Power | UC | DPP | Power |
| 5% | 0.93 | 1.38 | > 0.99 | 0.00 | 0.01 | 0.989 |
| 10% | 0.93 | 1.82 | > 0.99 | 0.00 | 0.02 | > 0.99 |
| 15% | 0.93 | 2.27 | > 0.99 | 0.00 | 0.04 | > 0.99 |
| 20% | 0.93 | 2.71 | > 0.99 | 0.00 | 0.05 | > 0.99 |
a
Assumes 2-sided with Bonferroni-adjusted type 1 error of 0.05/2 and n = 2000 eligible per cohort.
b
Proportion of DPP participants who enroll in the program (i.e., 5% = 100 DPP enrollees per cohort).
c
Assumes weight loss of 9.85 lbs for DPP enrollees.
d
Assumes HbA1c decrease of 0.24% for DPP enrollees.
DPP = Diabetes Prevention Program; HbA1c: hemoglobin A1c or glycated hemoglobin; UC = usual care.