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. 2022 May 9;13:876306. doi: 10.3389/fimmu.2022.876306

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Copyright © 2022 Paschold, Klee, Gottschick, Willscher, Diexer, Schultheiß, Simnica, Sedding, Girndt, Gekle, Mikolajczyk and Binder

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Matched pre- and post-SARS-CoV-2 vaccination blood sampling and global B cell repertoire analysis. (A) Vaccination and blood sampling scheme. (B) Broad B cell repertoire metrics. Bars indicate mean ± standard deviation. (C) Percentage of antigen experienced clones with somatic hypermutation (<98% identity to germline) per B cell repertoire. Box and whiskers plot are shown in the style of Tukey. (D) Quantitative connectivity analysis of B cell clones per repertoire. A clone is defined as a unique CDR3aa sequence. Clones are connected if they have a Levenshtein distance of ≤ 3 are connected. Boxes outline 25^th to 75^th percentile with a line at the median and whiskers from minimum to maximum. Petri dish plots of two representative pre-/post vaccination B cell repertoires are shown in brown and violet boxes on top (patients HACO-19 and DigiHero-12). Each dot in the petri dish plot represents one clone.