Table 3.
Cross-reactive HI antibody titers of the novel H5N6 viruses with antisera induced by different vaccine seed viruses or vaccines.
| Virus | Clade | HI antibody titer of antiserum induced by different antigensa | |||||
|---|---|---|---|---|---|---|---|
| H5-Re11 | H5-Re12 | H5-Re13 | H5-Re14 | H5 bivalent inactivated vaccine (H5-Re13 + H5-Re14) | H5/H7 trivalent inactivated vaccine (H5-Re13 + H5-Re14 + H7-Re4) | ||
| H5-Re11 | 2.3.4.4h | 512 | 32 | 512 | 128 | 512 | 512 |
| H5-Re12 | 2.3.2.1d | 32 | 512 | 64 | 32 | 64 | 64 |
| H5-Re13 | 2.3.4.4h | 32 | 4 | 512 | 4 | 512 | 512 |
| H5-Re14 | 2.3.4.4b | 16 | 4 | 32 | 512 | 512 | 512 |
| DK/GD/S4879/2020 | 2.3.4.4b | 8 | 2 | 32 | 256 | 256 | 512 |
| DK/GD/SE195/2021 | 2.3.4.4b | 32 | 16 | 128 | 1024 | 1024 | 2048 |
| DK/SC/S1805/2021 | 2.3.4.4b | 4 | 2 | 64 | 256 | 256 | 512 |
| CK/SN/SD001/2021 | 2.3.4.4b | 8 | 2 | 64 | 256 | 256 | 512 |
| CK/CQ/SD001/2021 | 2.3.4.4b | 4 | 2 | 64 | 256 | 256 | 512 |
| DK/SC/SD002/2021 | 2.3.4.4b | 4 | 2 | 64 | 256 | 256 | 512 |
| GS/CQ/SD003/2021 | 2.3.4.4b | 4 | 2 | 64 | 256 | 256 | 512 |
| DK/GX/S30428/2021 | 2.3.4.4b | 8 | 2 | 64 | 256 | 256 | 512 |
| DK/GX/S31116/2021 | 2.3.4.4b | 4 | 2 | 64 | 256 | 256 | 512 |
| DK/YN/S4318/2021 | 2.3.4.4b | 8 | 2 | 64 | 256 | 256 | 256 |
| DK/HuN/S40199/2021 | 2.3.4.4b | 8 | 2 | 64 | 256 | 256 | 512 |
| DK/HuN/S40268/2021 | 2.3.4.4b | 8 | 2 | 64 | 256 | 256 | 512 |
| DK/GZ/S4702/2021 | 2.3.4.4b | 4 | 2 | 64 | 256 | 256 | 512 |
| DK/ZJ/S4854/2021 | 2.3.4.4b | 8 | 2 | 64 | 256 | 256 | 512 |
| GS/GD/S4751/2021 | 2.3.4.4b | 8 | 2 | 64 | 256 | 256 | 512 |
a
Antisera were generated by vaccinating specific-pathogen-free chickens with the indicated oil-emulsified inactivated viruses or vaccines; the homologous titers are shown in bold.