TABLE E3.
Characteristics of pathological stage I non–small cell lung cancer in never-smokers versus ever-smokers
| Before matching | After matching | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
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| Characteristic | Never-smokers (n = 92) | Ever-smokers (n = 800) | Standardized difference, % | Never-smokers (n = 90) | Ever-smokers (n = 90) | Standardized difference, % | ||||
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| n* | No. (%) | n* | No. (%) | n* | No. (%) | n* | No. (%) | |||
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| Tumor location | 92 | 800 | 90 | 90 | ||||||
| Right upper | 31 (34) | 302 (38) | −8.4 | 30 (34) | 32 (36) | −3.4 | ||||
| Right middle | 2 (2.2) | 45 (5.6) | −18 | 2 (2.2) | 6.5 (7.2) | −23 | ||||
| Right lower | 25 (27) | 156 (19) | 18 | 25 (28) | 22 (24) | 7.7 | ||||
| Left upper | 20 (22) | 203 (26) | −8.6 | 18 (21) | 22 (25) | −10 | ||||
| Left lower | 14 (15) | 94 (12) | 10 | 14 (15) | 7.9 (8.8) | 20 | ||||
| Right central | 0(0) | 2 (0.25) | −7.1 | 0(0) | 0.03 (0.03) | −2.5 | ||||
| Left central | 0(0) | 1 (0.13) | −5.0 | 0(0) | 0.03 (0.03) | −2.5 | ||||
| Focality | 91 | 798 | 6.6 | 89 | 90 | −2.9 | ||||
| Unifocal | 84 (92) | 750 (94) | 83 (93) | 83 (92) | ||||||
| Multifocal | 7 (7.7) | 48 (6.0) | 6.1 (6.9) | 6.8 (7.6) | ||||||
| Histopathological type | 92 | 797 | 90 | 90 | ||||||
| Adenocarcinoma | 85 (92) | 534 (67) | 66 | 83 (92) | 82 (92) | 2.7 | ||||
| Large cell | 0(0) | 33 (4.1) | −29 | 0(0) | 2.4 (2.7) | −23 | ||||
| Not otherwise specified | 0(0) | 9(1.1) | −15 | 0(0) | 0.78 (0.87) | −13 | ||||
| Other | 4 (4.3) | 15 (1.9) | 14 | 3.9 (4.4) | 0.65 (0.73) | 23 | ||||
| Squamous | 3 (3.3) | 206 (26) | −68 | 3 (3.4) | 3.7 (4.2) | −4.3 | ||||
| Invasion and involved margins | ||||||||||
| Visceral pleural invasion | 90 | 16 (18) | 796 | 168 (21) | −8.4 | 88 | 16 (18) | 90 | 18 (20) | −5.4 |
| Lymphovascular invasion | 69 | 15 (22) | 600 | 151 (25) | −8.1 | 67 | 14 (20) | 70 | 17 (24) | −9.1 |
| Soft tissue margin involved | 75 | 2 (2.7) | 643 | 14 (2.2) | 3.2 | 73 | 2 (2.7) | 71 | 2 (2.8) | −0.61 |
| Bronchial margin involved | 83 | 3 (3.6) | 681 | 2 (0.29) | 24 | 81 | 3 (3.7) | 78 | 0.12 (0.15) | 26 |
| Vascular margin involved | 86 | 1 (1.2) | 678 | 1 (0.15) | 13 | 84 | 1 (1.2) | 78 | 0.02 (0.02) | 15 |
| Parenchymal margin involved | 54 | 0(0) | 540 | 5 (0.93) | −14 | 52 | 0(0) | 60 | 0.26 (0.43) | −9.2 |
| Pathological T category | 92 | 800 | 90 | 90 | ||||||
| 1a | 4 (4.4) | 95 (12) | −28 | 4 (4.5) | 11 (12) | −27 | ||||
| 1b | 40 (43) | 317 (40) | 7.8 | 39 (44) | 36 (41) | 6.5 | ||||
| 1c | 29 (32) | 255 (32) | −0.76 | 28 (31) | 28 (31) | −1.4 | ||||
| 2a | 19 (21) | 133 (17) | 10 | 19 (21) | 14 (16) | 13 | ||||
| Pathological N category | 92 | 800 | 90 | 90 | ||||||
| 0 | 92 (100) | 800 (100) | — | 90 (100) | 90 (100) | — | ||||
| Pathological M category | 92 | 92 (100) | 800 | 800 (100) | — | 90 | 90 (100) | 90 | 90 (100) | — |
| Pathological stage group | 92 | 800 | 17 | 90 | 90 | 19 | ||||
| IA1 | 4 (4.4) | 95 (12) | 4 (4.5) | 11 (12) | ||||||
| IA2 | 40 (43) | 317 (40) | 39 (43) | 36 (41) | ||||||
| IA3 | 29 (32) | 255 (32) | 28 (31) | 28 (31) | ||||||
| IB | 19 (21) | 133 (17) | 19 (21) | 14 (16) | ||||||
*
Patients with data available.