Fig. 2.

Joint associations of TV viewing (top panel) or computer use (bottom panel) and genetic risk with incident coronary heart disease (CHD). Cox regression models using age as the underlying timescale were adjusted for sex, body mass index (weight in kilograms/height in meters squared), smoking status (never, previous, current), employment (unemployed, employed), Townsend Deprivation Index (a numerical deprivation score generated based on employment, car ownership, home ownership and household overcrowding according to postcode of participants’ home address), alcohol consumption (never, previous, currently <3 times/week, currently ≥3 times/week), salt-adding behaviour (never/rarely, sometimes, usually, always), oily fish consumption (never, <once/week, once/week, >once/week), coffee intake (cups/day), fruit and vegetable intake (a composite score generated based on intake of fresh/dried fruit and intake of raw/cooked vegetable ranging from 0 to 4), processed/red meat intake (days/week), hypertension medication use, cholesterol-lowering medication use, glucose-lowering medication use, sleep (≤5, 6, 7, 8 and ≥9h/day), moderate-to-vigorous physical activity (minutes/day), genotype array type and first ten principal components of genetic ancestry, with mutual adjustment of the two exposure variables (TV viewing and computer use); no adjustment for the polygenic risk score. P values for multiplicative interactions between genetic risk and TV viewing and between genetic risk and computer use were 0.593 and 0.437, respectively. Rates are per 100,000 person-years. Abbreviations: HR hazard ratio, CHD coronary heart disease, CI confidence intervals