Table 3.

Pharmacokinetic parameters for PRI-724 and C-82 after PRI-724 infusion (Phase 1). The data is shown as mean and SD. NC: Not calculated.

		PRI-724				C-82
Dose (mg/m2/4h)		Tmax (h)	Cmax (ng/mL)	AUC 0-24h (ng•h/mL)	t1/2 (h)	Tmax (h)	Cmax (ng/mL)	AUC 0-24h (ng•h/mL)	t1/2 (h)
140	N	3	3	3	0	3	3	3	3
	Mean	2⋅3	1150	3740	NC	3⋅3	1230	5880	4⋅10
	S.D.	1⋅5	330	940	NC	1⋅2	250	1220	0⋅58
	CV (%)	65⋅2	28⋅7	25⋅1	NC	36⋅4	20⋅3	20⋅7	14⋅1
	Min	1	888	2790	NC	2	971	4530	3⋅49
	Max	4	1520	4660	NC	4	1460	6900	4⋅64
	Median	2⋅0	1030	3770	NC	4⋅0	1250	6210	4⋅17
280	N	6	6	6	2	6	6	6	6
	Mean	2⋅2	1710	5700	NC	4⋅0	2560	14400	3⋅85
	S.D.	1⋅5	620	1810	NC	0⋅0	690	5100	1⋅42
	CV (%)	68⋅2	36⋅3	31⋅8	NC	0⋅0	27⋅0	35⋅4	36⋅9
	Min	1	757	2650	0⋅444	4	1570	7860	2⋅78
	Max	4	2590	7500	0⋅475	4	3330	19400	6⋅58
	Median	1⋅5	1780	5960	0⋅460	4⋅0	2840	16600	3⋅46
380	N	6	6	6	4	6	6	6	6
	Mean	2⋅0	3530	11800	0⋅474	3⋅3	2770	14700	3⋅35
	S.D.	1⋅1	800	2700	0⋅034	1⋅0	1050	7600	0⋅46
	CV (%)	55⋅0	22⋅7	22⋅9	7⋅2	30⋅3	37⋅9	51⋅7	13⋅7
	Min	1	2590	7940	0⋅435	2	1300	5820	2⋅87
	Max	4	4730	16000	0⋅518	4	4010	25700	4⋅08
	Median	2⋅0	3540	11900	0⋅472	4⋅0	2740	12700	3⋅41