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. 2022 Mar 3;27(4):2255–2263. doi: 10.1038/s41380-022-01478-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — (i) Data preparation and multiple imputation of missing data were conducted in R; (ii) Factor analysis of ACEs was performed in Mplus, and Latent class growth analysis of CRP and depression was performed in Stata; (iii) Multinomial logistic regression analysis was conducted in Stata; (iv) Model-based causal mediation analysis was conducted in R.