Table 1.
Participant characteristics.
| EMIF | ADNI | |||||
|---|---|---|---|---|---|---|
| Characteristic | n | Mean/% | SD | n | Mean/% | SD |
| Age | 353 | 71.23 | 8.72 | 127 | 74.42 | 6.11 |
| Female | 182 | 51.6% | 50 | 39.4% | ||
| Education (in years) | 280 | 10.82 | 3.79 | 127 | 15.94 | 3.13 |
| Ancestry | ||||||
| European | 353 | 100% | – | 121 | 95.3% | – |
| African | – | – | – | 5 | 3.9% | – |
| Asian | – | – | – | 1 | 0.8% | – |
| Diagnosis | ||||||
| Cognitively normal | 45 | 12.5% | – | 62 | 49.6% | – |
| Subjective cognitive impairment | 22 | 7.10% | – | 0 | 0% | – |
| Mild cognitive impairment | 185 | 51.7% | – | 64 | 50.4% | – |
| Alzheimer’s disease | 101 | 28.7% | – | 0 | 0% | – |
| Mini-mental state examination | 350 | 25.01 | 4.50 | 127 | 28.20 | 1.63 |
| CSF biomarkers | ||||||
| β-Amyloid42 (in pg/ml) | 352 | 295.51 | 181.70 | 127 | 1024.60 | 476.99 |
| Tau (in pg/ml) | 351 | 318.27 | 344.14 | 127 | 276.32 | 101.78 |
| Phosphorylated Tau (in pg/ml) | 351 | 53.85 | 32.95 | 127 | 26.44 | 11.45 |
| Neurofilament light (in pg/ml) | 352 | 1315.39 | 2394.16 | 127 | 1299.76 | 1174.46 |
| YKL-40 (in pg/ml or z-scorea) | 353 | 176946.43 | 67909.97 | 63 | 0.00 | 0.85 |
| Neurogranin (in pg/ml) | 345 | 127.44 | 193.41 | 127 | 425.86 | 282.45 |
Demographic information and descriptive statistics.
n sample size, SD standard deviation.
aFor ADNI, average values of two peptide sequences, with two ion frequencies each, were averaged after z-score standardization.