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. 2022 Feb 8;27(4):2114–2125. doi: 10.1038/s41380-022-01452-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Effect sizes from ASD case-control analysis of node-level topological metric asymmetries that reflect global connectivity of each node, i.e., degree centrality and nodal global efficiency. b Effect sizes from ASD case-control analysis of nodal-level topological metric asymmetries that reflect local connectivity of each node, i.e., the clustering coefficient and nodal local efficiency. Positive effect sizes (pink-red) indicate shifts towards greater leftward or reduced rightward asymmetry in ASD compared to controls, and negative effect sizes (blue) represent shifts towards greater rightward asymmetry or reduced leftward asymmetry in ASD compared to controls.